Meet
Michael Ciarametaro

Managing Director

Michael Ciarametaro provides strategic advice to life sciences clients on developing value and evidence strategy and navigating the Inflation Reduction Act (IRA), drug pricing, and payment reform

In recent projects, Mike has helped life sciences companies strategize and prepare for Medicare drug pricing negotiations under the IRA by evaluating value propositions for therapies, advising on how to improve those value propositions, identifying key opportunities to engage policymakers, and delivering strategic recommendations to clients.

He has also guided clients in creating value strategies relevant to the Institute for Clinical and Economic Reviews product evaluations.

Before joining Avalere, Mike served as vice president of research at the National Pharmaceutical Council, where he developed and managed a strategic research portfolio focused on innovation (e.g., its value and its relationship to payment reform), and drug market access challenges and solutions. He also held positions at WellPoint and NetRx, and at Evidera where he led financial analysis supporting the Pharmacy and Therapeutics committee and developing strategies for drug pricing and device market access.

Mike holds a bachelors degree in electrical engineering from the University of Virginia and a Master of Business Administration from George Mason University.

Authored Content


A large share (30%) of beneficiaries access IPAYs 2026 or 2027 negotiated drugs through independent or franchise pharmacies.

Alternative approaches for weighting multiple uses of a product when setting maximum fair prices may better balance patient needs and development incentives.

The addition of 15 drugs selected for IPAY 2027 negotiation expand the impact maximum fair prices may have on key therapeutic areas and millions of beneficiaries.

The next cohort of drugs includes additional cancer and chronic disease therapies, as well as products that were therapeutic alternatives for IPAY 2026 drugs.

While the share of drugs covered on Part D formularies will increase slightly in 2025, more drugs will have coinsurance and utilization management.

Join our webinar to learn how Part D redesign and drug price negotiation will shape the Plan Year 2026 market, and what this means for manufacturers and plans.

Maximum fair prices for the first 10 selected drugs may shift therapeutic dynamics and have direct and indirect impact to millions of beneficiaries.

Avalere experts share initial impressions of the publicly released negotiated MFPs for the first round of selected drugs, highlighting implications to industry.

Updates in the Initial IPAY 2027 ICR highlight the increasing needs for specific evidence planning and generation for industry to prepare for negotiation.

On June 5, The Evidence Base published an article entitled, “Navigating uncertainty: redefining healthcare value in an evolving healthcare landscape,” covering key topics from Avalere’s ISPOR theater session. 

Manufacturers anticipating potential selection or therapeutic impact for 2027 Medicare negotiations should begin preparations and align internal decision-making, applying learnings from Year 1.

Ahead of Asembia 2024, Avalere experts discuss the evolution of biopharmaceutical value requirements and how organizations will need to evolve their business models accordingly.

Avalere experts dive into Trend #9: Policy’s Pressure on HEOR and explore implications of recent policy developments on evidence strategies.

In the next installment of our 2023 Top Trends in HEOR series, Avalere experts dive into Trend #9: Policy’s Pressure on HEOR.

ICER recently proposed piloting the GRACE framework in place of traditional cost-effectiveness analysis. We review the background of GRACE and its implications.

As the US value assessment landscape evolves, a new third-party framework may standardize requirements and open reimbursement pathways for digital health.

In Part 2 of our video series on the negotiated drug list, Avalere experts discuss topics including effectiveness measures that will inform CMS’s maximum fair price determinations, evidence generation strategies for manufacturers with products that have been selected for negotiation, or that are eligible for selection in the future, and CMS’s definition of therapeutic alternatives.

Manufacturers should reevaluate CMS engagement strategies as soon as possible to maximize the opportunity to influence the IPAY 2026 Medicare negotiations.

Delve into the far-reaching implications of the recently announced negotiated drug list as Avalere experts provide insights and answers to pressing questions surrounding CMS's landmark decision on Part D drug pricing and its impact on manufacturers, patients, and the future healthcare landscape.

CMS selected 10 Part D drugs for the first year of negotiation. Stakeholders should consider engagement opportunities and evaluate broader therapeutic dynamics.

Recently released guidance and a second draft Negotiation Data Elements ICR introduce several opportunities for patients and caregivers to shape negotiation.

ICER announced proposed changes to its Value Assessment Framework. Stakeholders have limited time to review and comment by June 30.

Manufacturers of therapeutic alternatives to negotiation-eligible drugs should re-examine their commercialization strategies in response to market dynamics.

Manufacturers of therapeutic alternatives to negotiation-eligible drugs should examine their value and evidence strategy in response to new dynamics.

Avalere’s expert presentations at ISPOR described the IRA’s impact on evidence strategy and highlighted a recent study to capture total disease burden.

Manufacturers may find significant gaps between their existing evidence and the negotiation data elements that CMS will evaluate during the negotiation process.

In response to IRA provisions, life sciences companies should reevaluate their pipeline investment and development strategies.

As CMS clarifies evidence requirements for drug price negotiations, manufacturers should prepare their strategies for asset development and on-market products.

In our Outlook 2023 webinar, Avalere expert Michael Ciarametaro discussed how evidence generation requirements will differ under the Inflation Reduction Act (IRA.)

CMMI releases long-awaited response to President Biden’s executive order on drug pricing with a directive for the Centers for Medicare & Medicaid Services (CMS) to develop three models.

Government price-setting provisions in the IRA have highlighted the diverse nature and interpretation of value across the US healthcare system.